Pharmacological effect of a new gel, which contains oak bark extract and aloe extract under the condition of experimental stomatitis in rats

Topicality. Aloe extract and oak bark extract are considered to be the most perspective medicinal raw materials in new drug development for dental practice.Aim. Aloe extract and oak bark extract are promising medicines for the development of a new drug for dental practice.Materials and methods. Experimental stomatitis was reconstituted by a one-time 5-second application with a cotton swab filled with a 10 % solution of sodium hydroxide. In the blood were investigated content of leukocytes and rate of erythrocyte sedimentation rate (ESR). The activity of catalase measured in tongue homogenate, and determined the content of reduced glutathione and thiobarbituric acid reagents. Metrogyl Denta was used as a comparison drug.Results and discussion. It was established that the new gel is likely to exceed the Metrogyl Denta for a decrease in the clinical parameters of stomatitis (hyperemia, edema, erosive-necrotic changes). The gel which contains oak bark extract and aloe extract have anti-inflammatory effect, reduces leukocytosis and ESR. The new gel have significant advantages over Metrogyl Denta, by high antioxidant effect, which is determined by the activity of catalase and indicators of reduced glutathione and thiobarbituric acid reagents.Conclusions. The new gel, which contains oak bark extract and aloe extract, is found to be an effective remedy for the treatment of experimental stomatitis, can be considered promising for further research and implementation into medical practice.