Key result
Hyponatraemia on admission for acute myocardial infarction was associated with significantly higher mortality compared to normal sodium levels (23.3% vs 12.1%; OR 2.2, 95% CI 1-4.9).
Why the study?
The usefulness of sodium levels in predicting mortality and morbidity following acute myocardial infarction was not established.
Does hyponatremia on admission predict mortality and morbidity in patients with acute myocardial infarction?
Cohort (n=177)
Does hyponatremia on admission predict mortality and morbidity in patients with acute myocardial infarction?
Odds Ratio: 2.2 (95% CI 1–4.9)
Absolute Event Rate: 23.3% vs 12.1%
Hyponatremia on admission in patients with acute myocardial infarction is a strong predictor of 60-day mortality and heart failure.
BACKGROUND study was conducted to determine the usefulness of sodium levels in predicting the mortality and morbidity following acute infarction. AND METHODS ethics committee approved the study and 177 consenting patients satisfying the inclusion criteria were enrolled. , demographic, clinical, biochemical, echocardiographic and ECG findings were recorded in semi structured questionnaire. sodium levels were estimated during admission. Parameters of outcome were death, heart failure, reinfarction, stroke, arrhythmia which were followed up clinically and by echocardiogram. Data analysis was done by SPSS®. Tests of significance bivariate logistic regression analysis were done to find out relationship between hyponatraemia and mortality and also the which are strongly correlated for the development of hyponatraemia. age of the study participants was 52.8 years and was predominantly composed of males. Statistically significant mortality noticed in hyponatraemia (23.3%) when compared with participants with normal sodium levels (12.1%) (OR-2.2; 95% CI 1 - 4.9). Diabetes was more common in hyponatraemia (68.6%) and 49.5% were diabetic among participants with normal levels (OR-2.2; 95% CI 1.2 -4.1). Hypertension was more common in hyponatraemia (60.5%) and 22% were among participants with normal sodium levels (OR-5.4; 95% CI 2.8 -10.5). Heart failure was more common among with hyponatraemia when compared to those with normal sodium levels (39.5% versus 23%) (OR-2.2; 95% CI 1.1 - 4.2). Ejection fraction <45% was more common in participants with hyponatraemia (53.5%) and in participants without (15.4%) (OR-6.4; 95% CI 3.1-12.9). Of the 54 participants who had anterior wall myocardial infarction, 41.9% hyponatraemia on admission and 19.8% having normal sodium levels (OR-2.9; 95% CI 1.5-5.7). presence of hyponatraemia during admission for acute myocardial infarction is a strong predictor of mortality and heart after 60 days of follow up. hyponatraemia is strongly correlated with male sex, diabetes mellitus, hypertension, anterior infarction.
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Thomas et al. (2018) conducted a cohort in acute myocardial infarction (n=177). Hyponatraemia vs. normal sodium levels was evaluated on mortality (OR 2.2, 95% CI 1 - 4.9). Hyponatraemia on admission for acute myocardial infarction was associated with significantly higher mortality compared to normal sodium levels (23.3% vs 12.1%; OR 2.2, 95% CI 1-4.9).
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