Key result
Hyponatremia in AMI is linked to ~100% higher mortality versus normal sodium levels.
Why the study?
Myocardial infarction is a leading cause of death and disability globally, prompting the study of hyponatremia as a prognostic indicator.
Does hyponatremia serve as a prognostic indicator for worse outcomes in patients with acute myocardial infarction?
Observational (n=100)
No
Does hyponatremia serve as a prognostic indicator for worse outcomes in patients with acute myocardial infarction?
Absolute Event Rate: 40% vs 20%
Hyponatremia in the setting of acute myocardial infarction is a marker of poorer prognosis, associated with higher Killip class, reduced ejection fraction, and increased mortality.
Background: Every year, myocardial infarction causes more deaths and disabilities than any other disease in the world, and In fact, it is the most prevalent form of a life-threatening chronic illness.Objectives: To study hyponatremia as a prognostic indicator in acute myocardial infarctionMethods: 100 patients with Acute Myocardial Infarction who were admitted to the ICU and the Department of Internal Medicine. All patients had a 12-lead ECG, with the right sided and posterior leads taken for inferior wall MI. A detailed history was collected, as well as a detailed clinical examination, as well as daily serum electrolytes and ECHO was done. An Ion selective electrode auto analyzer was used to determine the serum sodium concentration (Roche OMNIC).Results: In our study 64% were males and 36% were females. Males are more prone for ischemic heart diseases. The proportion of Diabetic, Smokers, hypertensives were more among patients with Hyponatremia. anterior wall MI was the most prevalent, followed by inferior wall MI. Killip class I is found in 74% of patients with normal sodium levels compared to 58% in hyponatremia groups, class II in 20% of patients compared to 24% in hyponatremia, class III in 6% of patients compared to 16% of hyponatremia patients, and class IV in 2% of hyponatremia patients whose sodium level was 130 or lower. Patients who developed hyponatremia had a greater mortality rate than those who had normal sodium levels.Conclusion: Asians are more likely to develop STEMI. The severe the Hyponatremia, the poorer the prognosis. Hyponatremia and a reduced ejection fraction are more common in anterior wall MI patients than those with normal sodium levels.
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Molugu et al. (2021) conducted an observational in Acute Myocardial Infarction (n=100). Hyponatremia (serum sodium < 135 mEq/L) vs. Normal sodium levels (>135 mEq/L) was evaluated on Mortality. Hyponatremia in patients with acute myocardial infarction was associated with a higher mortality rate (40%) compared to patients with normal sodium levels (20%).
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