Key result
Premature CAD is linked to ~72% higher arterial stiffness vs. controls.
Why the study?
Currently used risk algorithms poorly predict cardiovascular risk in individuals with a family history of premature CAD, necessitating novel risk assessment methods such as pulse-wave velocity.
Is pulse-wave velocity increased in first-degree relatives of patients with premature CAD compared to unrelated controls?
Case-Control (n=150)
No
Is pulse-wave velocity increased in first-degree relatives of patients with premature CAD compared to unrelated controls?
Odds Ratio: 1.72 (95% CI 1.32–2.24)
Absolute Event Rate: 9.69% vs 7.38%
p-value: p=<0.05
Pulse-wave velocity is increased in first-degree relatives of patients with premature CAD, suggesting arterial stiffness could serve as a novel marker for cardiovascular risk prediction in these families.
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May support PWV for risk stratification in familial premature CAD; leaves open incremental value over current algorithms.
Mulders et al. (2011) conducted a case-control in Premature coronary artery disease (n=150). Premature CAD and family history of premature CAD vs. Unrelated controls without CVD was evaluated on Pulse-wave velocity (PWV) (OR 1.72, 95% CI 1.32-2.24, p=<0.05). Patients with premature CAD and their first-degree relatives had significantly higher pulse-wave velocity compared with unrelated controls (OR 1.72 and OR 1.32, respectively), independent of other risk factors.
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