Key result
Torque Teno virus load is proposed as a potential surrogate marker for the net state of immunosuppression in transplant patients, addressing the limitations of strictly pharmacokinetic therapeutic drug monitoring.
Why the study?
Does Torque Teno virus load monitoring improve the assessment of the net state of immunosuppression in transplant patients compared to therapeutic drug monitoring?
Does Torque Teno virus load monitoring improve the assessment of the net state of immunosuppression in transplant patients compared to therapeutic drug monitoring?
Torque Teno virus load may serve as a surrogate marker for the net state of immunosuppression, potentially overcoming the limitations of strictly pharmacokinetic therapeutic drug monitoring.
Should not yet change immunosuppression monitoring in transplant recipients; leaves open prospective validation of TTV load as surrogate.
Transplant physicians still face challenges in assessing the net state of immunosuppression of their patients, which results from the complex interaction among pretransplant conditions, induction and maintenance immunosuppressive regimens, graft function, antirejection therapies, nutritional state and underlying comorbidities, and other factors. Therapeutic drug monitoring (TDM) of immunosuppressive agents appears as the most widely used strategy in current clinical practice. However, this approach is strictly pharmacokinetic in nature and does not capture the interindividual variability in T cell responses at a given concentration of calcineurin or mTOR inhibitors, or the synergistic effect of combination immunosuppressive regimens.
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Mario Fernández‐Ruiz (2020) conducted a review in Immunosuppression in transplant patients. Torque Teno virus load monitoring vs. Therapeutic drug monitoring (TDM) was evaluated. Torque Teno virus load is proposed as a potential surrogate marker for the net state of immunosuppression in transplant patients, addressing the limitations of strictly pharmacokinetic therapeutic drug monitoring.
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