Key result
Torque teno virus (TTV) load is associated with the risk of allograft rejection and infection in solid organ transplant recipients, serving as a potential biomarker to guide immunosuppression.
Why the study?
Potent immunosuppressive drugs require individual-level guidance to optimize efficacy and simultaneously detect overimmunosuppression and underimmunosuppression, moving beyond assays that evaluate only limited immune compartments.
Does TTV-guided immunosuppression reduce rejection and infection in solid organ transplant recipients?
Design
Review
Authors
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TTV load may inform immunosuppression titration in transplant recipients; hypothesis-generating and requires prospective validation before practice change.
Does TTV-guided immunosuppression reduce rejection and infection in solid organ transplant recipients?
TTV load monitoring represents a promising, integrated approach to characterize immune function and stratify the risk of rejection and infection in solid organ transplant recipients.
Jaksch et al. (2022) conducted a review in Solid organ transplantation. Torque teno virus (TTV) load monitoring was evaluated. Torque teno virus (TTV) load is associated with the risk of allograft rejection and infection in solid organ transplant recipients, serving as a potential biomarker to guide immunosuppression.
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