Key result
Higher baseline leukocyte count linked to ~26% increased risk of subarachnoid hemorrhage per SD.
Why the study?
The effect of systemic low-grade inflammation on incidence of subarachnoid haemorrhage was not known.
Does a higher baseline leukocyte count increase the incidence of subarachnoid haemorrhage in individuals free from previous stroke?
Cohort (n=19,794)
No
Does a higher baseline leukocyte count increase the incidence of subarachnoid haemorrhage in individuals free from previous stroke?
Hazard Ratio: 1.26 (95% CI 1.05–1.53)
p-value: p=0.014
High baseline leukocyte count is associated with an increased incidence of subarachnoid haemorrhage, particularly in smokers, suggesting a role for low-grade systemic inflammation.
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Leukocyte count should not guide SAH prevention; hypothesis-generating for inflammation in aneurysm rupture.
Söderholm et al. (2014) conducted a cohort in Subarachnoid haemorrhage (n=19,794). Leukocyte count vs. Lower leukocyte count (per 1 SD increase) was evaluated on Incidence of subarachnoid haemorrhage (HR 1.26, 95% CI 1.05-1.53, p=0.014). A one standard deviation increase in baseline leukocyte count was associated with a 26% increased risk of incident subarachnoid haemorrhage (HR 1.26) after adjustment for confounding factors.
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