Key result
Second-trimester plasma TAT levels > 3.9 μg/l strongly predicted subsequent preterm premature rupture of fetal membranes (OR 6.0; 95% CI 1.67-21.1).
Why the study?
Do elevated plasma thrombin-antithrombin (TAT) complexes predict preterm premature rupture of the fetal membranes (PPROM) in pregnant women?
Population
81 pregnant women
Comparison
Elevated plasma thrombin-antithrombin complexes vs Matched term controls with lower TAT levels
Design
Case-control
Follow-up
until delivery
Authors
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Elevated second-trimester TAT was associated with later PPROM; hypothesis-generating for thrombin-targeted prevention before clinical adoption.
Case-Control (n=81)
Do elevated plasma thrombin-antithrombin (TAT) complexes predict preterm premature rupture of the fetal membranes (PPROM) in pregnant women?
Odds Ratio: 6 (95% CI 1.67–21.1)
Second-trimester elevated plasma TAT concentrations are predictive of subsequent PPROM, providing further evidence that PPROM is associated with decidual thrombin activation.
Rosen et al. (2001) conducted a case-control in Preterm premature rupture of the fetal membranes (PPROM) (n=81). Second-trimester plasma TAT level > 3.9 μg/l vs. TAT level ≤ 3.9 μg/l was evaluated on Preterm premature rupture of the fetal membranes (PPROM) (OR 6.0, 95% CI 1.67-21.1). Second-trimester plasma TAT levels > 3.9 μg/l strongly predicted subsequent preterm premature rupture of fetal membranes (OR 6.0; 95% CI 1.67-21.1).
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