What type of study is this?

This is a Case-Control Study study.

What question did this study set out to answer?

This research evaluates serum acute phase reactants for early diagnosis of preterm prelabour rupture of membranes (PPROM).

November 14, 2025MedicineOpen Access

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Case-control study finds acute phase reactants improve diagnosis of preterm prelabour rupture of membranes, suggesting clinical utility.

This research evaluates serum acute phase reactants for early diagnosis of preterm prelabour rupture of membranes (PPROM).
Conducted a case-control study with 60 pregnant women with PPROM and 60 healthy controls.
Analyzed serum levels of acute phase reactants such as albumin, CRP, and fibrinogen.
Used logistic regression to determine predictive values and odds ratios for PPROM.
Lower albumin and factor 12 levels, higher CRP, sedimentation, ceruloplasmin, fibrinogen, and protein S values in PPROM patients.
AUC values indicated diagnostic effectiveness of various acute phase reactants for PPROM.
Logistic regression showed an 88.3% sensitivity for predicting PPROM.

Kızıldemir et al. (2025) studied this question.

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