Key result
High CV risk score linked to ~8.5-fold higher late arterial event risk after allogeneic HSCT.
Why the study?
Long-term outcome after allogeneic hematopoietic stem cell transplantation including late cardiovascular events and their risk factors was not well characterized.
What is the incidence and what are the risk factors for cardiovascular events in long-term survivors after allogeneic hematopoietic stem cell transplantation?
Population
548 long-term survivors after allogeneic HSCT in ten EBMT centers
Comparison
Patients with high global cardiovascular risk score vs low risk score
Design
Retrospective multicenter cohort study
Follow-up
15 years
Authors
Loading...
Supports closer CV risk monitoring in long-term allogeneic HSCT survivors; leaves open optimal prevention strategies in this population.
Cohort (n=548)
Yes
What is the incidence and what are the risk factors for cardiovascular events in long-term survivors after allogeneic hematopoietic stem cell transplantation?
Relative Risk: 8.51 (95% CI 3.45–20.99)
Absolute Event Rate: 17% vs 4%
p-value: p=<0.001
Long-term survivors of allogeneic hematopoietic stem cell transplantation face a notable risk of premature cardiovascular events, which is strongly associated with traditional cardiovascular risk factors.
Tichelli et al. (2008) conducted a cohort in Allogeneic hematopoietic stem cell transplantation (HSCT) survivors (n=548). High global cardiovascular risk score (≥50%) vs. Low global cardiovascular risk score (<50%) was evaluated on First arterial event (cerebral, coronary, or peripheral) at 15 years (RR 8.51, 95% CI 3.45-20.99, p=<0.001). A high global cardiovascular risk score in long-term survivors of allogeneic hematopoietic stem cell transplantation was associated with an 8.5-fold increased risk of late arterial events (RR 8.51).
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: