Key result
Gene editing using the CRISPR/Cas system represents a potential novel treatment approach for chronic pathogenic diseases caused by DNA viruses that cannot be cured by currently available drugs.
Gene editing using the CRISPR/Cas system represents a potential novel therapeutic approach for chronic pathogenic diseases caused by DNA viruses.
May expand options for DNA virus diseases; leaves open clinical validation before practice change.
The emergence of the CRISPR/Cas system of antiviral adaptive immunity in bacteria as a facile system for gene editing in mammalian cells may well lead to gene editing becoming a novel treatment for a range of human diseases, especially those caused by deleterious germline mutations. Another potential target for gene editing are DNA viruses that cause chronic pathogenic diseases that cannot be cured by using currently available drugs. We review the current state of this field and discuss the potential advantages and problems with using a gene editing approach as a treatment for diseases caused by DNA viruses.
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Kennedy et al. (2016) conducted a review in Viral diseases (DNA viruses). Gene editing (CRISPR/Cas) was evaluated. Gene editing using the CRISPR/Cas system represents a potential novel treatment approach for chronic pathogenic diseases caused by DNA viruses that cannot be cured by currently available drugs.
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