Key result
MDCT-derived LV shape, size, and stiffness predict early CAD with an AUC over ~80%.
Why the study?
Cardiac multi-detector computed tomography is widely used to diagnose CAD, but informative predictors from left ventricular characteristics in early CAD patients need identification.
Do left ventricular shape, size, and stiffness on MDCT predict early coronary artery disease?
Observational (n=42)
Do left ventricular shape, size, and stiffness on MDCT predict early coronary artery disease?
Left ventricular shape, size, and stiffness derived from MDCT images are effective indicators for early coronary artery disease, showing good agreement with physician judgments.
Answers are grounded in this paper and cite their sources.
LV metrics on MDCT may predict early CAD; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: Coronary artery disease (CAD) remains the leading cause of death worldwide. Currently, cardiac multi-detector computed tomography (MDCT) is widely used to diagnose CAD. The purpose in this study is to identify informative and useful predictors from left ventricular (LV) in the early CAD patients using cardiac MDCT images. MATERIALS AND METHODS: Study groups comprised 42 subjects who underwent a screening health examination, including laboratory testing and cardiac angiography by 64-slice MDCT angiography. Two geometrical characteristics and one image density were defined as shape, size and stiffness on MDCT image. The t-test, logistic regression, and receiver operating characteristic curve were applied to assess and identify the significant predictors. The Kappa statistics was used to exam the agreements with physician's judgments (i.e., Golden of True, GOT). RESULTS: The proposed three characteristics of LV MDCT images are important predictors and risk factors for the early CAD patients. These predictors present over 80% of AUC and higher odds ratio. The Kappa statistics was 0.68 for the combinations of shape and stiffness into logistic regression. CONCLUSIONS: The shape, size and stiffness of the left ventricular on MDCT can be used to be the effective indicators in the early CAD patients. Besides, the combinations of shape and stiffness into logistic regression could provide substantial agreement with physician's judgments.
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Lu et al. (2016) conducted an observational in Early coronary artery disease (n=42). Left ventricular shape, size, and stiffness on MDCT was evaluated on Prediction of early CAD. Left ventricular shape, size, and stiffness on MDCT were significant predictors of early coronary artery disease, presenting an AUC of over 80%.
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