Key result
Epicardial fat volume (AUC 0.813) and calcium score (AUC 0.947) assessed by MDCT demonstrated high diagnostic value for predicting coronary artery disease activity.
Why the study?
Current MDCT systems enable visualization of cardiac volume with high density resolution, but the diagnostic value of MDCT in assessing epicardial adipose tissue in coronary artery disease required evaluation.
Does MDCT assessment of epicardial adipose tissue volume and calcium score predict coronary artery disease in patients with acute coronary syndrome?
Observational (n=75)
Does MDCT assessment of epicardial adipose tissue volume and calcium score predict coronary artery disease in patients with acute coronary syndrome?
Effect estimate: AUC 0.813 for EFV; AUC 0.947 for Ca score
MDCT-derived epicardial fat volume and calcium score are effective predictors of coronary artery disease in patients presenting with acute coronary syndrome.
Hypothesis-generating for MDCT epicardial fat and calcium metrics in CAD activity; prospective validation required before clinical adoption.
Background: Current Multi Detector Computed Tomography (MDCT) systems allow the visualization of the entire heart volume during an entire heart cycle with high density resolution. MDCT imaging is thus opened to a wide spectrum of cardiac applications. This study aimed to evaluate out the diagnostic value of multi detector computed tomographic in assessment of epicardial adipose tissue with coronary artery disease. Methods: This Prospective, non-controlled nonrandomized study was conducted on 75 patients who underwent CT angiogram due to acute coronary syndrome occurrence. For further assessment of CAD patients divided into two groups: non-CAD group: 25 subjects with normal coronary arteries and CAD group: 50 subjects with coronary artery lesion. Results: This study included 75 patients; their mean age was 61.85 years. 61% of the studied subjects were males and 38% were females. ROC curve of EFV was conducted for prediction of CAD disease activity. EFV showed 0.813 area under curve at cut off level 60.39 with good sensitivity and specificity. ROC curve of Ca score was conducted for prediction of CAD disease activity. Ca score showed 0.947 area under curve at cut off level 90 with high sensitivity and specificity. Conclusion: The EAT volume has good prognostic value for developing CAD and increased EAT is considered a risk factor for CAD. Ca score could have an appropriate prognostic value for the determination of coronary artery disease.
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Refaat et al. (2023) conducted an observational in Coronary artery disease (n=75). Epicardial fat volume (EFV) and Calcium (Ca) score via MDCT vs. Normal coronary arteries was evaluated on Prediction of CAD disease activity (AUC 0.813 for EFV; AUC 0.947 for Ca score). Epicardial fat volume (AUC 0.813) and calcium score (AUC 0.947) assessed by MDCT demonstrated high diagnostic value for predicting coronary artery disease activity.
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