Evaluation of the relation between epicardial adipose tissue and hepatosteatosis with coronary atherosclerosis using multidetector computed tomography

Background: In this study, the relationship of CAD (coronary artery disease) with EAT (epicardial adipose tissue) volume and hepatosteatosis were investigated by using multidetector computed tomography (MDCT). Material and Method: EAT (Epicardial Adipose Tissue) volume, CCS (coronary calcium score) and CT density of liver (CTDL) were measured by using 64-detector computed tomography in 96 patients who were clinically referred for the evaluation of CAD. The relationship between EAT volume, CCS, CTDL and their effectiveness in detecting coronary heart disease were investigated. Data analysis was done with MedCalc (Version 9.6.2.0) package program. Results: CCS (AUC=0.866) and EAT volume (AUC=0.672) were significantly effective in determination of CAD. The diagnostic accuracy of CCS in detecting CAD was higher than of EAT volume. EAT volume was higher in patients with CAD (85.81±34.51 cm³), compared to patients without CAD (68.38±29.23 cm³) (P=0.0119). CTDL in patients with CAD (58.74±12.22 HU) was significantly lower than in patients without CAD (63.02±8.93) (P=0.0553). There was no statistically significant relationship between EAT volume and CCS (r=0.1620, P=0.1148), EAT volume and CTDL (r=0.0046, P=0.9648), and CCS and CTDL (r=0.0109, P=0.9162). Conclusion: There was no relationship between EAT volume, CTDL and CCS. EAT volume is higher in patients with CAD than in patients without CAD. EAT volume had moderate but lower diagnostic power than CCS, to determine CAD.