Key result
CETP rs708272 G allele is linked to ~47% higher risk of myocardial infarction.
Why the study?
The TaqI B (rs708272) variant in the CETP gene is actively investigated as a risk factor for lipid metabolism disorders and myocardial infarction risk in the white population of Western Siberia.
Is the rs708272 CETP gene variant associated with altered lipid profile parameters and an increased risk of myocardial infarction in the white population of Western Siberia?
Observational (n=3,132)
Is the rs708272 CETP gene variant associated with altered lipid profile parameters and an increased risk of myocardial infarction in the white population of Western Siberia?
Odds Ratio: 1.465 (95% CI 1.028–2.087)
p-value: p=0.036
The G allele of the CETP gene variant rs708272 is associated with lower HDL cholesterol, higher atherogenicity, and an increased risk of myocardial infarction in a white Siberian population.
Should not yet inform MI risk assessment; leaves open replication of CETP rs708272 association beyond Siberian whites.
The TaqI B (rs708272) single-nucleotide variant, i.e., the +279 G/A substitution in intron 1 of the CETP gene, is actively investigated as a risk factor of lipid metabolism disorders. The aim of this study was to analyze the association of rs708272 with lipid parameters and the risk of myocardial infarction in the population of Western Siberia (Russia). The study population was selected from a sample surveyed within the framework of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) study (9360 participants, >90% white, aged 45–69 years, males: 50%). In total, 3132 randomly selected patients were included. Plasma lipid levels were determined by standard enzymatic assays. Rs708272 was analyzed by RT-PCR via TaqMan single-nucleotide polymorphism (SNP) Genotyping Assays (Thermo Fisher Scientific, USA). The frequencies of rs708272 genotypes AA (homozygote), AG (heterozygote), and GG were 0.21, 0.49, and 0.30, respectively, in this population. Allele A frequency was 0.46. We found an association of allele G with low levels of high-density lipoprotein cholesterol and a high index of atherogenicity in this population (p < 0.001 and p < 0.001, respectively). Allele G was significantly associated with the risk of myocardial infarction among the male participants (odds ratio 1.96, 95% confidence interval 1.208–3.178, p = 0.008) and in the study population (odds ratio 1.465, 95% confidence interval 1.028–2.087, p = 0.036). Thus, rs708272 is associated with myocardial infarction in the white population of Western Siberia (Russia).
No takes yet. Share an insight, caveat, or question.
Semaev et al. (2019) conducted an observational in Myocardial infarction (n=3,132). rs708272 (CETP Gene Variant) Allele G vs. Allele A / non-carriers was evaluated on Risk of myocardial infarction (OR 1.465, 95% CI 1.028-2.087, p=0.036). The CETP gene variant rs708272 allele G was significantly associated with an increased risk of myocardial infarction in the overall study population (OR 1.465; 95% CI 1.028-2.087; p=0.036).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: