Key result
Metabolic syndrome is linked to roughly double the rate of coronary interventional complications.
Why the study?
The influence of endothelial dysfunction and metabolic syndrome on complications after interventional treatment in patients with coronary heart disease was not well defined.
Does the presence of metabolic syndrome worsen endothelial dysfunction and increase complications following interventional treatment in patients with coronary heart disease?
Cohort (n=154)
No
Does the presence of metabolic syndrome worsen endothelial dysfunction and increase complications following interventional treatment in patients with coronary heart disease?
Absolute Event Rate: 29.8% vs 14.1%
p-value: p=<0.05
Patients with coronary heart disease and metabolic syndrome exhibit more pronounced endothelial dysfunction and face a significantly higher risk of complications and restenosis following interventional treatment.
Metabolic syndrome was associated with higher interventional complications in CHD; leaves open endothelial dysfunction mediation and need for prospective validation.
Aim. To assess the influence of endothelial dysfunction and metabolic syndrome on interventional treatment coronary complications development in patients with coronary heart disease. Methods. 57 patients with coronary heart disease and concomitant metabolic syndrome (the main group) and 64 patients with coronary heart disease alone (the comparison group) were included in the study. Control group for endothelial function parameters included 33 healthy blood donors. Endothelial function was assessed by plasma and erythrocyte nitrate level, plasma L-arginine level and desquamated endothelial cell blood count before the interventional treatment and after its completion. Results. Initial signs of endothelial dysfunction were observed in both groups of patients compared to the controls. Desquamated endothelial cell blood count was significantly higher in patients with metabolic syndrome than in the comparison group. Only the desquamated endothelial cell blood count increased significantly after the interventional treatment, the difference was more pronounced (р 0.05) in patients with metabolic syndrome. Complications of interventional treatment in patients with and without symptoms of metabolic syndrome were observed in 29.8 and 14.1% respectively (р 0.05). The number of coronary artery restenoses was significantly higher in the main group than in the comparison group (12.2 and 3.1% respectively). Conclusion. Initially endothelial dysfunction was more pronounced in patients with metabolic syndrome. A significant increase of endothelial dysfunction was observed in patients of the main group after the interventional treatment. The number of interventional treatment complications and coronary arteries restenoses was significantly higher in patients with coronary heart disease and concomitant metabolic syndrome.
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Arsenitcheva et al. (2013) conducted a cohort in Coronary heart disease (n=154). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Complications of interventional treatment (p=<0.05). Concomitant metabolic syndrome in patients with coronary heart disease significantly increased the rate of interventional treatment complications to 29.8% compared to 14.1% in patients without metabolic syndrome.
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