Key result
High molecular weight PEG grafting via glutaraldehyde significantly reduces bovine pericardium in vitro calcification.
Why the study?
Calcification frequently causes clinical failure of bio-prosthetic heart valves made from glutaraldehyde pretreated bovine pericardium, and methods to reduce calcification are needed.
Does polyethylene glycol (PEG) grafting of bovine pericardium reduce in vitro calcification and improve mechanical stability compared to other grafting methods?
Does polyethylene glycol (PEG) grafting of bovine pericardium reduce in vitro calcification and improve mechanical stability compared to other grafting methods?
Surface modification of bovine pericardium with high molecular weight PEG via glutaraldehyde linkages may reduce tissue calcification and improve biodegradation resistance for bioprosthetic heart valves.
Calcification is a frequent cause of the clinical failure of bio-prosthetic heart valves fabricated from glutaraldehyde pretreated bovine pericardium (GATBP). This article reports on various chemical techniques for grafting polyethylene glycol (PEG) on bovine pericardium, their biostability, and calcification. The process of calcification profile was studied by in vitro experiments via the incubation of pericardial samples in a metastable solution of calcium phosphate. The calcification profile of PEG-modified bovine pericardium through glutaraldehyde linkages was significantly reduced compared to other methods of grafting. The mechanical property of these PEG-modified tissues after enzyme (collagenase) digestion and calcification were also investigated. PEG grafting of BP via glutaraldehyde or hexamethylene diisocyanate had shown better mechanical stability compared to other grafting methods used. In conclusion, it seems that the surface modification of bovine pericardium through high molecular weight PEGs via glutaraldehyde linkages may provide new ways of controlling tissue biodegradation and calcification.
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Vasudev et al. (1997) studied Calcification of bio-prosthetic heart valves. Polyethylene glycol (PEG) grafting via glutaraldehyde linkages vs. Other methods of grafting was evaluated on Calcification profile and mechanical stability. Surface modification of bovine pericardium through high molecular weight PEGs via glutaraldehyde linkages significantly reduced in vitro calcification compared to other grafting methods.
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