Key result
Diabetes, but not nondiabetic metabolic syndrome, is linked to higher NT-proBNP and mortality in CAD.
Why the study?
The influence of metabolic syndrome and diabetes mellitus on NT-proBNP levels and its prognostic performance in coronary artery disease patients was unclear.
Does the presence of metabolic syndrome and diabetes mellitus influence NT-proBNP levels and its prognostic performance for all-cause death in patients with coronary artery disease?
Cohort (n=1,638)
Does the presence of metabolic syndrome and diabetes mellitus influence NT-proBNP levels and its prognostic performance for all-cause death in patients with coronary artery disease?
p-value: p=0.004
NT-proBNP remains a reliable independent predictor of all-cause mortality in CAD patients, even in the presence of confounding factors like metabolic syndrome and diabetes.
NT-proBNP independently predicts death in CAD regardless of MetS or DM; leaves open whether MetS-adjusted thresholds enhance stratification.
OBJECTIVES: Our aim was to investigate whether the presence of metabolic syndrome (MetS) and diabetes mellitus (DM) influenced the N-terminal pro-B-type natriuretic peptide (NT-proBNP) level and its prognostic performance in coronary artery disease (CAD). PATIENTS AND METHODS: The present study enrolled a total of 1638 CAD patients. Multivariate regression analyses were carried out to relate NT-proBNP to metabolic components, nondiabetic MetS, DM, and MetS score. Furthermore, we examined the prognostic performance of NT-proBNP in patients with non-MetS, nondiabetic MetS, and DM. RESULTS: NT-proBNP levels correlated inversely with BMI (β=-0.11, P=0.003) and correlated positively with fasting glucose (β=0.12, P=0.001). There were no significant relationships of NT-proBNP with other metabolic parameters. Compared with non-MetS, the presence of DM significantly increased NT-proBNP levels (P=0.004), whereas nondiabetic MetS did not influence NT-proBNP levels (P=0.954). During the median follow-up of 21 months, 109 all-cause deaths occurred. NT-proBNP levels independently predicted all-cause deaths irrespective of the presence of nondiabetic MetS and DM (Pinteraction=0.43). CONCLUSION: DM, but not nondiabetic MetS, is associated with higher NT-proBNP levels. NT-proBNP can still predict death in patients with CAD, even with the confounding effect of MetS and diabetes.
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Huang et al. (2016) conducted a cohort in Coronary artery disease (CAD) (n=1,638). Diabetes mellitus and nondiabetic metabolic syndrome vs. Non-metabolic syndrome (non-MetS) was evaluated on NT-proBNP levels and all-cause death (p=0.004). Diabetes mellitus, but not nondiabetic metabolic syndrome, was associated with higher NT-proBNP levels (P=0.004), and NT-proBNP independently predicted all-cause death in CAD patients.
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