Key result
Serum cystatin C levels showed a significant but moderate correlation with serum creatinine levels (Spearman's ρ=0.693, P=0.001) and increased in an age-dependent manner in patients with lung cancer.
Why the study?
How do serum cystatin C levels correlate with creatinine, age, BMI, CRP, and disease extent in elderly lung cancer patients?
Observational (n=39)
No
How do serum cystatin C levels correlate with creatinine, age, BMI, CRP, and disease extent in elderly lung cancer patients?
Effect estimate: Spearman's ρ 0.693
p-value: p=0.001
Serum cystatin C correlates with creatinine and increases with age in lung cancer patients, suggesting age adjustment is necessary when estimating renal function.
May warrant age adjustment for cystatin C renal estimates in lung cancer; leaves open utility versus creatinine.
The purpose of this study was to confirm the correlation between serum levels of cystatin C (Cys-C) and those of creatinine (Cre), the most widely used index of renal function in clinical practice, and to evaluate serum levels of Cys-C, with a particular focus on the effects of aging, body mass index (BMI), C-reactive protein (CRP) and disease extent in patients with lung cancer. Serum Cys-C levels in a total of 39 patients (median 72 years), who were diagnosed as having lung cancer were analyzed retrospectively. The serum Cys-C was determined using colloidal gold particles coated with anti-Cys C antibodies. A significant correlation coefficient was found between serum levels of Cys-C and those of Cre (P=0.001), but only moderate agreement. Serum Cys-C levels increased in an age-dependent manner with significant differences among 3 age groups: patients younger than 65 years, those aged 65 to 74 years and those aged 75 years or older (P=0.001). However, no correlation was observed between Cys-C and BMI, Cys-C and CRP, or Cys-C and disease extent of lung cancer. Estimation of renal function is important since renal insufficiency is directly correlated to increased chemotherapeutic complications in oncological practice. Thus, estimation of serum Cys-C levels may be important, but adjustment of Cys-C for age should be taken into consideration.
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Ohara et al. (2011) conducted an observational in Lung cancer (n=39). Serum cystatin C was evaluated on Correlation between serum cystatin C and creatinine levels (Spearman's ρ 0.693, p=0.001). Serum cystatin C levels showed a significant but moderate correlation with serum creatinine levels (Spearman's ρ=0.693, P=0.001) and increased in an age-dependent manner in patients with lung cancer.
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