Key result
Adding D-dimer to the ESC model improves 30-day PE mortality discrimination to AUC 0.85.
Why the study?
Acute pulmonary embolism has high early mortality, and validating predictive models helps identify patients for appropriate treatment settings.
Does the 2014 ESC prognostic model, with or without D-dimer, accurately predict 30-day mortality in patients with acute pulmonary embolism?
Population
272 consecutive patients with acute PE diagnosed by angiography chest CT or perfusion lung scan
Comparison
ESC 2014 prognostic model for early mortality with vs without D-dimer measurement
Design
Single-centre cohort study
Follow-up
30 days
Authors
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May improve acute PE risk stratification; extends ESC model but hypothesis-generating and should not yet change practice.
Cohort (n=272)
No
Does the 2014 ESC prognostic model, with or without D-dimer, accurately predict 30-day mortality in patients with acute pulmonary embolism?
Effect estimate: AUC 0.77 (95% CI 0.67-0.87)
The 2014 ESC predictive model accurately predicts 30-day mortality in acute pulmonary embolism, and its performance is further improved by incorporating D-dimer levels at diagnosis.
Cugno et al. (2018) conducted a cohort in Acute pulmonary embolism (n=272). ESC prognostic model was evaluated on Early mortality within 30 days (AUC 0.77, 95% CI 0.67-0.87). The ESC prognostic model showed good discriminatory power for 30-day mortality in acute pulmonary embolism (AUC 0.77; 95% CI 0.67-0.87), which further increased to 0.85 when D-dimer was added.
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