Key result
High-sensitivity troponins achieve <10% CV precision at the 99th percentile and detect measurable levels in healthy subjects.
Why the study?
The troponin literature has reached a tipping point necessitating guidance on the use of high-sensitivity troponins from specialist societies.
High-sensitivity troponin assays require specific decision limits based on the 99th percentile upper reference limit and guidance from specialist societies for clinical application.
Supports hs-troponin assay validation at 99th percentile; leaves open standardization of clinical thresholds pending specialist guidance.
Troponin is vital in the evaluation of acute coronary syndrome. Decision limits, based on the 99 th percentile upper reference limit derived from a sufficiently large normal reference population, must be determined for each specific troponin method. The new troponins exhibit high-sensitivity performance – assay precision at less than 10% coefficient of variation (at the 99 th percentile upper reference limit) and ability to detect measurable values in healthy subjects. The troponin literature has reached a tipping point necessitating guidance on its use from specialist societies.
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Tar Choon Aw (2012) conducted a review in Acute coronary syndrome. High-sensitivity troponins was evaluated. High-sensitivity troponins exhibit assay precision at less than 10% coefficient of variation at the 99th percentile upper reference limit and can detect measurable values in healthy subjects.
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