Key result
Carotid sinus nerve stimulation prolongs the cardiac cycle by ~43% vs baseline in dogs.
Why the study?
The phase dependency of heart rate response to carotid sinus nerve stimulation and its effect on cardiac pacemaker synchronization were not fully characterized.
Population
Anesthetized open-chest dogs
Comparison
Carotid sinus nerve stimulation vs prestimulation control
Design
Preclinical experimental study
Authors
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Phase-specific baroreflex stimulation may optimize reflex responses; leaves open translation to human therapies.
Absolute Event Rate: 583% vs 408%
Demonstrates phase-dependent synchronization of the cardiac pacemaker with repetitive carotid sinus nerve stimulation in a canine model.
Levy et al. (1972) studied this question. Repetitive stimulation of the carotid sinus nerve vs. Prestimulation control was evaluated on Cardiac cycle (P-P interval) prolongation. Right carotid sinus nerve stimulation in dogs prolonged the cardiac cycle to a mean of 583 msec from a prestimulation control of 408 msec when the P-St interval was approximately zero.
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