Key result
Chronic warfarin therapy can trigger spontaneous thyroid hemorrhage causing acute, potentially lethal airway obstruction.
Why the study?
Spontaneous bleeding into the thyroid gland is rare but can cause potentially lethal acute airway compromise, especially in patients on chronic anticoagulation therapy.
Case Report (n=1)
Chronic anticoagulation with warfarin can rarely lead to spontaneous thyroid hemorrhage and potentially lethal acute airway compromise.
Rare thyroid hemorrhage on warfarin may cause acute airway obstruction; single case leaves open incidence and prevention strategies.
Even though highly vascularized, the thyroid gland rarely has spontaneous bleeding. Bleeding into the thyroid gland can result in potentially lethal acute airway compromise. This case report describes an elderly patient on warfarin for atrial fibrillation, who presented with swelling on the right side of her neck causing acute airway obstruction. An urgent computed tomography of the neck showed an enlarging hemorrhage into the right lobe of the thyroid gland. She was initially intubated for airway protection and her anticoagulation was reversed to stop the bleeding. She was closely monitored in the intensive care unit. After an uncomplicated tracheal extubation and recovery, she was discharged and scheduled for an elective total thyroidectomy. We desire that physicians be aware of this rare, potentially lethal bleeding complication.
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Gunasekaran et al. (2017) conducted a case report in Atrial fibrillation (n=1). Warfarin was evaluated. Chronic warfarin therapy for atrial fibrillation can rarely lead to spontaneous thyroid hemorrhage and potentially lethal acute airway obstruction, requiring urgent reversal and airway protection.
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