Key result
Acute blood volume expansion fails to increase cardiac output or VO2 max during exercise.
Why the study?
The maximum cardiac output during exercise may be limited by extracardiac factors affecting ventricular filling or by the heart itself, requiring investigation.
Does acute expansion of blood volume increase maximum cardiac output during maximum exertion in men with normal cardiovascular systems?
Comparison
Acute expansion of blood volume via infusion of 1000 to 1200 ml of autologous blood vs baseline
Design
Physiological study of acute blood volume expansion
Follow-up
Acute during exercise
Authors
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Modest exercise cardiac output rise with blood volume expansion; leaves open whether cardiac or extracardiac factors primarily limit maximum output.
Does acute expansion of blood volume increase maximum cardiac output during maximum exertion in men with normal cardiovascular systems?
Acute blood volume expansion does not increase maximum cardiac output during exercise, suggesting the upper limit of cardiac output is determined by the heart itself rather than extracardiac factors.
Robinson et al. (1966) studied Normal cardiovascular system (n=6). Acute expansion of blood volume (autologous blood infusion) was evaluated on Cardiac output and maximum O2 uptake during exercise. Acute expansion of blood volume by 1000-1200 ml during exercise caused a large increase in central venous pressure but no significant increase in cardiac output or maximum O2 uptake.
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