Key result
Recent genome-wide association studies and gene expression profiling have yielded new insights into the genetics of essential hypertension, though questions remain regarding clinical significance.
Why the study?
Insight into the genetics of essential hypertension is needed, including methods used in human and animal studies and interpretation of results.
Recent advances in GWAS and gene expression profiling provide new insights into the genetic basis of essential hypertension, though challenges in data interpretation remain.
Advances hypertension genetics research; leaves open clinical translation pending validation.
PURPOSE OF REVIEW: To provide insight into genetics of essential hypertension, including discussion of methods used both in human and animal experimental studies and interpretation of results. RECENT FINDINGS: On the basis of recent progress in sequencing of human genome, detection of millions of single nucleotide polymorphism markers, determination of the extend of linkage disequilibrium (haplotypes), efficient genotyping technology, collection of DNA from thousands of rigorously phenotyped patients and controls and designing sound statistical methods, genome-wide associations studies were widely applied to analyses of common diseases including essential hypertension for the first time in 2007. Concurrently, new experimental approaches combined gene expression profiling with linkage and correlation analyses to identify quantitative trait loci underlying complex traits at the molecular level. SUMMARY: These new approaches yielded new exciting results but also posed questions regarding data analyses, interpretation and clinical significance.
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Pravenec et al. (2008) conducted a review in Essential hypertension. Genome-wide association studies and gene expression profiling was evaluated. Recent genome-wide association studies and gene expression profiling have yielded new insights into the genetics of essential hypertension, though questions remain regarding clinical significance.
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