Key result
Computed tomography changes correlated well with the degree of histologic response to preoperative high-dose methotrexate in 7 of 9 patients (77.8%) with nonmetastatic osteosarcoma.
Why the study?
Does CT evaluation accurately assess the histologic response of nonmetastatic extremity osteosarcoma to preoperative high-dose intravenous methotrexate?
Population
9 patients with nonmetastatic osteosarcoma of an extremity
Comparison
CT scan evaluation after four courses of… vs Initial CT scan at presentation
Design
Case_series
Authors
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CT changes may correlate with histologic response in osteosarcoma; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=9)
Does CT evaluation accurately assess the histologic response of nonmetastatic extremity osteosarcoma to preoperative high-dose intravenous methotrexate?
CT evaluation can effectively assess the histologic response of osteosarcoma to preoperative high-dose methotrexate.
Mail et al. (1985) conducted an observational in Nonmetastatic osteosarcoma of an extremity (n=9). Computed tomography (CT) was evaluated on Correlation of CT changes with histologic response (degree of tumor necrosis). Computed tomography changes correlated well with the degree of histologic response to preoperative high-dose methotrexate in 7 of 9 patients (77.8%) with nonmetastatic osteosarcoma.
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