Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease
Key result
NAFLD susceptibility genes show no association with coronary artery disease risk.
- OR 1.0
- 95% CI 0.99-1.00
- n=184,305
Why the study?
Coronary artery disease is the principal cause of death in patients with nonalcoholic fatty liver disease, but whether NAFLD is causally involved in CAD pathogenesis is unclear.
Are NAFLD susceptibility genes causally associated with coronary artery disease?
Population
60,801 CAD cases and 123,504 controls from CARDIoGRAMplusC4D Consortium
Comparison
12 NAFLD susceptibility genes vs controls without CAD
Design
Observational genetic association study
Authors
Discussion
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Member takes
Implication
Genetically predicted NAFLD links to CAD after VLDL variant exclusion; leaves open causality and should not yet alter clinical risk stratification.
Study Design
Type
Observational (n=184,305)
Multicenter
Yes
Structured PICO
Are NAFLD susceptibility genes causally associated with coronary artery disease?
P
Population
184,305 individuals (60,801 CAD cases and 123,504 controls) from the CARDIoGRAMplusC4D Consortium.
E
Exposure
12 nonalcoholic fatty liver disease (NAFLD) susceptibility genes
C
Comparator
Controls without CAD / baseline genetic risk
O
Outcome
Coronary artery disease (CAD)hard clinical
Main Result
Odds Ratio: 1 (95% CI 0.99–1)
NAFLD susceptibility genes do not cause CAD per se; their relationship with CAD appears to depend largely on plasma lipids.
Cite This Study
Brouwers et al. (2019) conducted an observational in Coronary artery disease and nonalcoholic fatty liver disease (n=184,305). NAFLD susceptibility genes vs. Non-risk alleles was evaluated on Coronary artery disease (OR 1.0, 95% CI 0.99-1.00). The combination of 12 NAFLD susceptibility genes was not associated with coronary artery disease (OR 1.0; 95% CI 0.99-1.00), indicating these genes do not cause CAD per se.