Key result
Elevated CRP affects ~40% of newly diagnosed T2D patients, linked to sex-specific lifestyle risks.
Why the study?
The prevalence of and modifiable factors associated with elevated C-reactive protein in newly diagnosed Type 2 diabetes patients in a population-based setting were not well characterized.
What is the prevalence of and what modifiable factors are associated with elevated CRP in newly diagnosed Type 2 diabetes mellitus patients?
Cross-Sectional (n=1,037)
Yes
What is the prevalence of and what modifiable factors are associated with elevated CRP in newly diagnosed Type 2 diabetes mellitus patients?
In newly diagnosed Type 2 diabetes, 40% of patients have elevated CRP, with associated modifiable risk factors differing by gender.
Elevated CRP in new T2DM should not yet change practice; leaves open gender-specific modifiable factor trials.
BACKGROUND: We aimed to examine the prevalence of and modifiable factors associated with elevated C-reactive Protein (CRP), a marker of inflammation, in men and women with newly diagnosed Type 2 Diabetes mellitus (DM) in a population-based setting. METHODS: CRP was measured in 1,037 patients (57% male) with newly diagnosed Type 2 DM included in the prospective nationwide Danish Centre for Strategic Research in Type 2 Diabetes (DD2) project. We assessed the prevalence of elevated CRP and calculated relative risks (RR) examining the association of CRP with lifestyle and clinical factors by Poisson regression, stratified by gender. We used linear regression to examine the association of CRP with other biomarkers. RESULTS: The median CRP value was 2.1 mg/L (interquartile range, 1.0 - 4.8 mg/L). In total, 405 out of the 1,037 Type 2 DM patients (40%) had elevated CRP levels (>3.0 mg/L). More women (46%) than men (34%) had elevated CRP. Among women, a lower risk of elevated CRP was observed in patients receiving statins (adjusted RR (aRR) 0.7 (95% confidence interval (CI) 0.6-0.9)), whereas a higher risk was seen in patients with central obesity (aRR 2.3 (95% CI 1.0-5.3)). For men, CRP was primarily elevated among patients with no regular physical activity (aRR 1.5 (95% CI 1.1-1.9)), previous cardiovascular disease (aRR1.5 (95% CI 1.2-1.9) and other comorbidity. For both genders, elevated CRP was 1.4-fold increased in those with weight gain >30 kg since age 20 years. Sensitivity analyses showed consistent results with the full analysis. The linear regression analysis conveyed an association between high CRP and increased fasting blood glucose. CONCLUSIONS: Among newly diagnosed Type 2 DM patients, 40% had elevated CRP levels. Important modifiable risk factors for elevated CRP may vary by gender, and include low physical activity for men and central obesity and absence of statin use for women.
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Svensson et al. (2014) conducted a cross-sectional in Newly diagnosed Type 2 Diabetes mellitus (n=1,037). Lifestyle and clinical factors (e.g., central obesity, physical inactivity, statin use) vs. Absence of respective risk factors was evaluated on Elevated C-reactive protein (>3.0 mg/L). Among newly diagnosed Type 2 diabetes patients, 40% had elevated CRP levels, with risk factors varying by gender, including central obesity and absence of statin use for women, and low physical activity for men.