Exercise-induced ST segment elevation. Electrocardiographic, angiographic, and scintigraphic evaluation.
Key result
Post-MI exercise-induced ST elevation is linked to LV wall motion abnormalities in ~100% of patients.
- n=215
Why the study?
Exercise-induced ST segment elevation over the infarct zone in patients with previous myocardial infarction and its underlying mechanisms were not well characterized.
Does exercise-induced ST segment elevation in leads with a 'QS' configuration correlate with left ventricular wall motion abnormalities in patients with previous myocardial infarction?
Comparison
Patients with exercise-induced ST segment elevation vs those without
Design
Observational study with electrocardiographic, scintigraphic, and angiographic evaluation
Authors
Discussion
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Implication
May indicate LV dysfunction post-MI; hypothesis-generating for risk stratification, prospective studies needed.
Study Design
Type
Observational (n=215)
Structured PICO
Does exercise-induced ST segment elevation in leads with a 'QS' configuration correlate with left ventricular wall motion abnormalities in patients with previous myocardial infarction?
P
Population
215 patients with previous myocardial infarction evaluated 4 to 6 months after the acute episode using exercise electrocardiography.
E
Exposure
Computer assisted 12 lead exercise electrocardiography, with a subset of 36 patients further investigated by serial thallium-201 scintigraphy, coronary arteriography, and left ventricular angiography.
O
Outcome
Presence of left ventricular wall motion abnormalities and left ventricular aneurysm (dyskinesia and akinesia) in patients with exercise-induced ST segment elevation.surrogate
Exercise-induced ST segment elevation in leads with a 'QS' configuration after myocardial infarction strongly correlates with severe underlying left ventricular wall motion abnormalities (aneurysm) rather than reversible ischemia.
Cite This Study
Lahiri et al. (1980) conducted an observational in Previous myocardial infarction (n=215). Exercise-induced ST segment elevation was evaluated on Left ventricular wall motion abnormalities. Exercise-induced ST segment elevation over the infarct zone in patients with previous myocardial infarction indicated left ventricular wall motion abnormalities in 100% of cases and aneurysm in 89%.