Key result
Pancreatic shear wave velocity was significantly higher in women than in men (1.44 vs 1.19 m/s in the pancreatic head) and increased significantly with advancing age.
Why the study?
What is the influence of gender, age, BMI, alcohol consumption, and smoking on shear wave velocity of the pancreas in healthy volunteers?
Cross-Sectional (n=234)
No
What is the influence of gender, age, BMI, alcohol consumption, and smoking on shear wave velocity of the pancreas in healthy volunteers?
Absolute Event Rate: 1.44% vs 1.19%
p-value: p=<0.0001
Pancreatic shear wave velocity measured by ARFI-VTQ is significantly influenced by age and sex, with higher values in women and older individuals.
Pancreatic p-SWE reference ranges should account for age and sex; leaves open whether adjustments improve diagnostic accuracy in disease.
PURPOSE: A variety of elastographic techniques have been developed to facilitate the non-invasive assessment of tissue properties. The goal of the study was to examine the influence of gender, age, BMI, alcohol consumption, and smoking in healthy volunteers. METHODS: Of the 263 participants who met all the study inclusion criteria, 234 had successful measurements. The examination was performed with the Siemens Acuson S3000 (Siemens Healthcare, Erlangen, Germany), using the 6C1 curved array transducer with the virtual touch tissue quantification (VTQ) method. RESULTS: The values determined with the curved array in the head of the pancreas were 1.44 ± 0.39 m/s for women and 1.19 ± 0.29 m/s for men; in the body, the results were 1.49 ± 0.37 m/s for women and 1.26 ± 0.30 m/s for men; in the tail, the corresponding values were 1.29 ± 0.36 m/s for women and 1.05 ± 0.30 m/s for men. Comparison of gender showed that men have significantly lower mean values than women. There were significantly higher values in all parts of the organ with the increasing age of the participants (p < 0.0001). For BMI, there was a significant correlation with the values only when considering the BMI in continuous form. Alcohol consumption and smoking did not have any significant effects. CONCLUSIONS: ARFI-VTQ is qualified for use on pancreatic tissue. Further studies are required to examine the influence of other factors in larger populations.
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Stumpf et al. (2016) conducted a cross-sectional in Healthy volunteers (n=234). Demographic and lifestyle factors (age, gender, BMI, alcohol, smoking) vs. Reference groups (e.g., men, younger age) was evaluated on Shear wave velocity in the head of the pancreas (p=<0.0001). Pancreatic shear wave velocity was significantly higher in women than in men (1.44 vs 1.19 m/s in the pancreatic head) and increased significantly with advancing age.
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