Key result
Hodgkin lymphoma chemoradiotherapy is linked to ~70% LAD stenosis presenting 16 months post-treatment.
Why the study?
The short latency period from Hodgkin's lymphoma treatment to symptomatic coronary artery disease is unusual compared to the typical several years.
Case Report (n=1)
No
This case highlights the potential for accelerated, symptomatic coronary artery disease occurring unusually early (16 months) after chest radiotherapy and doxorubicin therapy for Hodgkin's lymphoma.
May warrant heightened ischemia vigilance in young mediastinal radiotherapy survivors; leaves open optimal screening strategies.
We present the case of a 30 year-old woman - 16 months after successful treatment of Hodgkin's lymphoma (chest location) with chemotherapy (including doxorubicin) and radiotherapy - with recurrent chest pain and dyspnea. In ambulatory event telemetry, she reported nocturnal chest pain with transient ST elevation characteristic for acute cardiac ischemia. Urgent coronary angiography with intravascular ultrasound and virtual histology visualization revealed 70% fibrotic stenosis in the proximal segment of the left anterior descending artery successfully treated with a drug-eluting stent implantation. This case is especially noteworthy because of the short period from initial therapy to the symptomatic coronary artery disease that is entirely unlike the reported mean latency period of several years.
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Krzesiński et al. (2013) conducted a case report in Unstable angina and coronary artery disease (n=1). Chemotherapy and radiotherapy was evaluated on Coronary artery stenosis. A 30-year-old woman developed unstable angina and 70% fibrotic stenosis in the left anterior descending artery just 16 months after chemotherapy and radiotherapy for Hodgkin's lymphoma.
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