Key result
Pregnancy in renal transplant recipients taking cyclosporin A resulted in 44 live births out of 52 pregnancies, with frequent complications of prematurity and hypertension but no fetal malformations.
Why the study?
What are the pregnancy outcomes in renal transplant recipients taking cyclosporin A and corticosteroids?
Observational (n=33)
What are the pregnancy outcomes in renal transplant recipients taking cyclosporin A and corticosteroids?
Pregnancy in renal transplant recipients on cyclosporin A is generally successful with no fetal malformations, though frequently complicated by prematurity and hypertension.
May inform counseling on pregnancy in cyclosporin-treated renal transplant recipients; leaves open confirmation in prospective studies.
SummaryThe outcome of 52 pregnancies in 33 renal allograft recipients is reported. All patients were treated with cyclosporin A and corticosteroid immunosuppression. There were 44 live born babies (one twin pregnancy), two stillbirths, five middle trimester spontaneous abortions and two induced abortions for medical indications. The most frequent complications were prematurity and hypertension. Thirty of the deliveries were preterm and 12 of the babies had a birth weight below the 10th centile. Eight pregnancies were complicated by pregnancy induced hypertension and another seven had hypertension worsened by pregnancy.In this group of patients, pregnancy after transplantation was usually associated with a successful outcome and no fetal malformations were observed.
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Sabagh et al. (1995) conducted an observational in Pregnancy in renal transplant recipients (n=33). Cyclosporin A and corticosteroid immunosuppression was evaluated on Pregnancy outcome (live births, abortions, complications). Pregnancy in renal transplant recipients taking cyclosporin A resulted in 44 live births out of 52 pregnancies, with frequent complications of prematurity and hypertension but no fetal malformations.
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