Key result
Conception under two years post-renal transplant links to worse pregnancy outcomes with ~22% prematurity.
Why the study?
The correlation between pregnancy outcome, pregnancy complications, and transplantation-to-pregnancy interval in renal transplant recipients was not well defined.
Do complications in pregnancy and a shorter transplantation-to-pregnancy interval worsen pregnancy outcomes in renal transplant recipients?
Population
23 pregnancies in renal transplant recipients in Croatia after prepregnancy stabilization
Comparison
Pregnancy outcomes by transplantation-to-pregnancy interval and pregnancy complications
Design
Retrospective cohort analysis
Authors
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Supports cautious preconception counseling in renal transplant recipients; hypothesis-generating and requires validation in larger prospective cohorts.
Cohort (n=23)
Do complications in pregnancy and a shorter transplantation-to-pregnancy interval worsen pregnancy outcomes in renal transplant recipients?
A transplantation-to-conception interval of less than 2 years and poor allograft function during pregnancy are associated with worse obstetric outcomes in renal transplant recipients.
Kuvačić et al. (2000) conducted a cohort in Renal transplant recipients (n=23). Arterial hypertension, elevated serum creatinine, bacteriuria, and conception <2 years after transplantation was evaluated on Pregnancy outcome (abortions, preterm deliveries, low birth weight). Among 23 pregnancies in renal transplant recipients, the prematurity rate was 21.7%, and conception <2 years post-transplant or poor graft function was associated with worse obstetric outcomes.
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