Key result
Pregnancy in women with a prior renal transplant resulted in a live birth in 84% of cases, though prepregnancy serum creatinine ≥1.5 mg/dL was associated with preterm delivery and low birth weight.
Why the study?
What are the perinatal outcomes in women with a prior renal transplant?
Observational (n=60)
No
What are the perinatal outcomes in women with a prior renal transplant?
Pregnancy in renal transplant recipients has a high rate of live births (84%), though prepregnancy serum creatinine ≥1.5 mg/dL is associated with preterm delivery and low birth weight.
May inform preconception counseling after renal transplant; leaves open validation of creatinine thresholds in prospective studies.
OBJECTIVE: To assess pregnancy outcomes in a population of renal transplant recipients in Mexico. METHOD: A total of 75 pregnancies in 60 patients managed at the National Institute of Perinatology, Mexico City, Mexico, were reviewed. RESULT: The mean age at conception was 26.97+/-5.42 years and the mean time from transplantation to pregnancy was 5.49+/-3.6 years. Prepregnancy renal function was determined by serum creatinine level (mean, 1.32+/-0.73 mg/dL). Prepregnancy hypertension was noted in 45.3% of the patients. Urinary tract infection was the most common complication, followed by pregnancy-induced hypertension. The pregnancy resulted in abortion in 11 patients and in live birth for the remaining 64 participants. The mean+/-SD gestational age at birth was 37.1+/-3 weeks, and intrauterine growth restriction was noted in 12 newborns. A serum creatinine level of 1.5 mg/dL or higher prior to pregnancy was associated with delivery before the 34th week and low birth weight. CONCLUSION: In this study, pregnancy ended in a live birth in 84% of women with a renal transplant.
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Cruz-Lemini et al. (2007) conducted an observational in Pregnancy in renal transplant recipients (n=60). Prior renal transplantation was evaluated on Live birth. Pregnancy in women with a prior renal transplant resulted in a live birth in 84% of cases, though prepregnancy serum creatinine ≥1.5 mg/dL was associated with preterm delivery and low birth weight.
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