Key result
Aconitine induces left superior vena cava ectopic pacemakers that drive atrial tachycardia.
Why the study?
The mechanism of aconitine-induced ectopic pacemaker formation and arrhythmias in the left superior vena cava proximal to the heart was not fully understood.
Aconitine induces ectopic pacemaker activity in the rabbit left superior vena cava, providing a model for studying arrhythmogenesis.
Animal data on aconitine-induced LSVC pacemakers offer no clinical guidance; leaves open translational relevance to human SVT.
The ectopic pacemaker formation by aconitine in the left superior vena cava proximal to the heart was studied in rabbit.(1) Aconitine produced the automatic activities in the isolated strip of vena caval muscle.(2) During the recovery from aconitine poisoning the action potentials with diastolic slow depolarization were recorded from the region of the left superior vena cava near the coronary sinus.(3) In the in situ experiment, tachycardia was produced by the local application to the left superior vena cava near the coronary sinus.(4) From the above-mentioned facts, it was suggested that aconitine induced the ectopic pacemaker in the left superior vena cava proximal to the heart and that the impulse from the ectopic focus spread not only to the periphery but also to the atrium.
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YANAGA et al. (1966) studied Aconitine-induced arrhythmias. Aconitine was evaluated on Induction of automatic activities and ectopic pacemaker formation. Aconitine induced ectopic pacemaker activity in the left superior vena cava proximal to the heart in rabbits, with impulses spreading to the atrium and causing tachycardia.
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