Key result
The third trimester of normal pregnancy was associated with a significantly higher mean plasma adenosine concentration (0.41 +/- 0.08 microM) than the first and second trimesters (p < 0.05).
Observational (n=11)
Plasma adenosine concentration increases in the third trimester of normal pregnancy, which may be attributed to enhanced release from activated platelets.
Adenosine elevation in third-trimester pregnancy warrants no clinical action; hypothesis-generating for platelet mechanisms and maternal-fetal outcomes.
The aim of this study was to measure changes in plasma adenosine concentration [ADO] during a normal pregnancy and to evaluate the possible role of platelets and red blood cells (RBC) as causes of changes in plasma [ADO]. We measured the plasma [ADO] in normal pregnant women (n = 11) during the first, second and third trimesters. The mean plasma [ADO] in the third trimester was 0.41 +/- 0.08 microM (means +/- SEM), significantly higher than in the first and second trimesters (p < 0.05). In pregnant women, platelet and RBC counts, hematocrit and hemoglobin concentration decreased slightly throughout the pregnancy. The elevation in the plasma [ADO] correlated inversely with the platelet count (r = -0.43, p < 0.05). These results suggest that an increase in the plasma [ADO] in the third trimester may be attributed to the enhanced adenosine release from activated platelets.
No takes yet. Share an insight, caveat, or question.
Yoneyama et al. (2000) conducted an observational in Normal pregnancy (n=11). Third trimester of pregnancy vs. First and second trimesters was evaluated on Plasma adenosine concentration (p=<0.05). The third trimester of normal pregnancy was associated with a significantly higher mean plasma adenosine concentration (0.41 +/- 0.08 microM) than the first and second trimesters (p < 0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: