Key result
Bidisomide slows Vmax recovery kinetics with an ~9-minute time constant unlike flecainide or lidocaine.
Why the study?
The onset and recovery kinetics of rate-dependent Vmax reduction by class I antiarrhythmic agents, including bidisomide, were not fully characterized or compared.
Population
Guinea pig papillary muscles
Comparison
Bidisomide versus lidocaine, flecainide, and disopyramide
Design
Preclinical experimental study
Authors
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Requires validation in human tissue before any clinical consideration; extends preclinical kinetic profiling of class I agents.
Bidisomide exhibits slow onset kinetics similar to flecainide and very slow recovery kinetics similar to disopyramide, leading to frequency-independent Vmax reduction.
Martin et al. (1991) studied this question. Bidisomide (SC-40230) vs. Lidocaine, flecainide, and disopyramide was evaluated on Onset and recovery kinetics of rate-dependent Vmax reduction. Bidisomide and disopyramide caused frequency-independent Vmax reduction with very slow recovery time constants (8.8 and 2.4 min, respectively), unlike flecainide and lidocaine.
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