Key result
MVP syndrome is linked to ~9-fold higher early repolarization frequency vs. healthy controls.
Why the study?
Mitral valve prolapse syndrome is correlated with increased frequency of cardiac dysrhythmias and sudden death, but the frequency of early repolarization in ECG between MVP patients and healthy adults was not well characterized.
Is early repolarization on ECG more frequent in patients with mitral valve prolapse syndrome compared to healthy adults?
Cross-Sectional (n=200)
Is early repolarization on ECG more frequent in patients with mitral valve prolapse syndrome compared to healthy adults?
Absolute Event Rate: 74% vs 8%
p-value: p=0.0001
Early repolarization on ECG is significantly more prevalent in young patients with symptomatic mitral valve prolapse syndrome compared to healthy individuals.
Early repolarization in MVP may warrant arrhythmia monitoring; cross-sectional data leave open any causal or prognostic link.
INTRODUCTION: Mitral valve prolapse syndrome (MVP) is the most common valvular abnormalityin the young and is correlated with increased frequency of cardiac dysrhythmias and sudden death.The aim of this study was to compare frequency of "early repolarization" in electrocardiogram(ECG) between MVP patients and healthy adults. METHODS: In this cross-sectional study, we compared ECG presentations of early repolarizationincluding notch in descending arm of QRS and J-point and/or ST segment changes in 100 patientswith MVP with 100 healthy individuals. MVP patients were referred to cardiology clinic withsymptoms of palpitation, chest pain or anxiety. RESULTS: The mean age in patients with MVP was significantly less than healthy subjects (29.5 ±9.3 years versus 31.0 ± 6.9 years in control group, P= 0.1967). We detected early repolarizationas a prevalent sign in ECG of patients which was a notch in descending arm of QRS and/or STsegment or J-point elevation seen in 74% of patients ( 51% in inferior leads and 23% in I and aVLleads) , whilst the same findings were seen in 8 men (8%) in control group (P= 0.0001). CONCLUSION: Early repolarization in ECG presented as a notch in descending arm of QRS and/or ST segment or J-point elevation is more frequent in in young patients with MVP syndrome.
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Alizadehasl et al. (2014) conducted a cross-sectional in Mitral valve prolapse syndrome (MVP) (n=200). Mitral valve prolapse syndrome vs. Healthy individuals was evaluated on Frequency of early repolarization in electrocardiogram (ECG) (p=0.0001). Mitral valve prolapse syndrome was associated with a significantly higher frequency of early repolarization on ECG compared to healthy controls (74% vs 8%, P=0.0001).
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