Mirtazapine-Induced Thrombocytopenia and Neutropenia

Neutropenia is a rare and commonly reversible side effect of antidepressant treatment [1]. Mirtazapine is a noradrenergic and specific serotonergic antidepressant that is approved for use in the treatment of major depression in many countries [2]. A major hematological side effect of mirtazapine is agranulocytosis. Herein we report a patient with depression that developed severe neutropenia-associated thrombocytopenia during treatment with mirtazapine; the patient was safely treated by switching to another drug.