Key result
Cardiopulmonary bypass is linked to increased oxidative stress and impaired plasma antioxidant capacity.
Why the study?
Cardiopulmonary bypass patients undergoing heart valve replacement surgery experience oxidative stress, but the timing and changes in iron-binding and iron-oxidising plasma antioxidants during surgery were not fully characterized.
Does cardiopulmonary bypass surgery induce sequential oxidative stress and alter antioxidant activities in patients undergoing heart valve replacement?
Observational
Does cardiopulmonary bypass surgery induce sequential oxidative stress and alter antioxidant activities in patients undergoing heart valve replacement?
Cardiopulmonary bypass during heart valve replacement surgery induces significant sequential oxidative stress and depletes plasma antioxidant activities, particularly during extracorporeal circulation and myocardial reperfusion.
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May inform antioxidant strategies in bypass; leaves open whether reducing oxidative stress improves outcomes.
Pepper et al. (1994) conducted an observational in Cardiopulmonary bypass patients undergoing heart valve replacement surgery. Cardiopulmonary bypass surgery vs. Normal healthy controls was evaluated on Oxidative stress markers (protein and lipid damage, lipid peroxides, thiobarbituric acid-reactive substances, plasma iron-binding and iron-oxidising antioxidant activities). Cardiopulmonary bypass surgery was associated with increased oxidative stress, including rises in lipid peroxides and decreases in plasma iron-binding and iron-oxidising antioxidant activities.
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