Key result
White matter lesions in AD linked to ~68% higher hypertension prevalence.
Why the study?
The role of vascular risk factors in Alzheimer's disease has not been investigated in relation to neuroimaging findings.
Is small vessel disease associated with higher blood pressure and pulse pressure in patients with Alzheimer's disease?
Cross-Sectional (n=152)
Is small vessel disease associated with higher blood pressure and pulse pressure in patients with Alzheimer's disease?
Absolute Event Rate: 75.6% vs 45.1%
p-value: p=0.03
In Alzheimer's disease, the presence of small vessel disease on MRI is associated with higher blood pressure and pulse pressure, suggesting a heterogeneous vascular contribution to the syndrome.
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Higher BP and wider pulse pressure associate with SVD in AD patients; leaves open distinct vascular subtypes and need for prospective trials before practice change.
F-E de Leeuw (2004) conducted a cross-sectional in Alzheimer's disease (n=152). Small vessel disease (white matter lesions and lacunar infarcts) vs. Without small vessel disease was evaluated on Hypertension prevalence (p=0.03). In Alzheimer's disease patients, the presence of white matter lesions was associated with a higher prevalence of hypertension (75.6% vs 45.1%; p=0.03) and higher pulse pressure.
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