The presence of thyroglobulin (Tg) in the blood circulation in a wide variety of concentrations is an intriguing phenomenon in thyroid pathology, taking into account that no physiological role for Tg outside the thyroid is known. However, the tissue-specific origin of Tg has made this protein very applicable as a diagnostic marker in various diseases of the thyroid, such as differentiated thyroid cancer, subacute thyroiditis, Graves’ disease and congenital thyroid diseases. This, in spite of the fact that the mechanisms by which Tg is released and the molecular structure in which it appears in the circulation are poorly understood. The paper by Druetta et al. (1) aims to provide more insight into these questions.
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Vijlder et al. (1999) studied this question.
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