Key result
APOA5 -1131T>C variant linked to higher triglycerides and lower HDL-C in specific constitution groups.
Why the study?
The association of the APOA5 gene -1131T>C polymorphism with serum lipids shows inconsistent results across ethnic and racial groups, including Koreans.
Does the APOA5 gene -1131T>C polymorphism associate with altered serum lipid levels differently across Sasang constitution groups in Korean subjects?
Cross-Sectional (n=1,619)
Yes
Does the APOA5 gene -1131T>C polymorphism associate with altered serum lipid levels differently across Sasang constitution groups in Korean subjects?
The APOA5 -1131T>C polymorphism is associated with lower HDL-C and higher triglycerides in specific Sasang constitution groups among Korean subjects.
APOA5 -1131T>C distribution does not differ by Sasang constitution; leaves open genetic influences on constitution-specific lipid profiles.
Apolipoprotein A5 (APOA5) was identified as a strong modulator of serum lipids. Moreover, an APOA5 gene -1131T>C polymorphism has been associated with serum lipids, but the results are inconsistent according to ethnic and racial groups. We have genotyped and analyzed 1,619 outpatients of Korean oriental medicine hospitals who were classified into three Sasang constitution groups (SCGs), So-Yang (SY), So-Eum (SE), and Tae-Eum (TE). There were no significant difference in the distribution of the APOA5 -1131T>C genotype among the three SCGs. Subjects with the C allele in SY and TE showed significantly lower serum high-density lipoprotein cholesterol (HDL-C) and higher triglyceride (TG) levels than noncarriers of the C allele. These results show the differences in the prevalence of decreasing serum HDL-C and elevating serum TG levels along with APOA5 -1131T>C polymorphism according to SCG and suggest that SCG may act as a significant risk factor for hypo-HDL-C-emia and hypertriglyceridemia susceptibility.
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Song et al. (2011) conducted a cross-sectional in Serum lipids (n=1,619). APOA5 gene -1131T>C polymorphism (C allele) vs. Noncarriers of the C allele was evaluated on Serum HDL-C and triglyceride levels. The APOA5 -1131T>C polymorphism C allele was associated with significantly lower serum HDL-C and higher triglyceride levels in the So-Yang and Tae-Eum Sasang constitution groups.
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