Key result
3'-terminal RNA stem-loop structures and poly(U) tracts protected RNA substrates from 3'-->5' exonuclease degradation in vitro.
RNA structures and poly(U) tracts protect RNA from 3'-->5' exonuclease degradation in vitro.
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Suggests strategies to improve RNA stability; leaves open in vivo roles in cardiovascular gene regulation.
Leigh Ford (1999) studied this question. 3'-Terminal RNA structures and poly(U) tracts vs. Unstructured RNA / absence of poly(U) tracts was evaluated on Protection from 3'-->5' exonuclease activity. 3'-terminal RNA stem-loop structures and poly(U) tracts protected RNA substrates from 3'-->5' exonuclease degradation in vitro.
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