Key result
Elevated serum ACE levels are linked to stroke and TIA compared to healthy controls.
Why the study?
An abnormal balance between oxidative and protective mechanisms and high plasma ACE levels may contribute to cerebrovascular disease, but comparative data with healthy controls are needed.
Are serum ACE and oxidative stress markers altered in patients with cerebrovascular disorders compared to healthy controls?
Cross-Sectional (n=120)
No
Are serum ACE and oxidative stress markers altered in patients with cerebrovascular disorders compared to healthy controls?
Absolute Event Rate: 27.5% vs 22.61%
p-value: p=<0.004
Elevated serum ACE and oxidative stress markers are associated with acute ischemic stroke and TIA, potentially contributing to disease severity.
Elevated serum ACE in stroke/TIA is hypothesis-generating; leaves open prognostic value or therapeutic targeting pending prospective data.
Objective: Several studies indicate the existence of an abnormal balance between the oxidative and protective mechanisms in patients can be a causative factor for cerebrovascular disease. High plasma levels of angiotensin-converting enzyme (ACE) contribute to the development of vascular diseases. Serum ACE and antioxidant levels were determined in cerebrovascular disorders (CVD) and compared between CVD and healthy person. Methods: A cross-sectional study was conducted on 50 cases of stroke and 10 cases of transient ischemic attack (TIA) with 60 controls matched for age and sex. Fasting blood samples were estimated for serum angiotensin-converting enzyme, serum lipid profile, MDA, SOD, and serum Vitamin E). ACE was estimated by spectrophotometry. The levels of ACE were correlated with the severity and outcome of the stroke. Results: The level of serum ACE was significantly higher in stroke (27.50±1.14U/L) and TIA (31.60±2.02 U/L) as compared to controls (22.61±0.79 U/L). Fasting blood sugar, total cholesterol, triglycerides, LDL cholesterol, and MDA were significantly increased whereas a significant decrease was observed in serum HDL, erythrocyte SOD, and Vitamin E levels in cerebrovascular disease patients as compared to the control group. Statistical p<0.05 was considered significant. Conclusion: Oxidative stress is a potential contributor to acute ischemic stroke and TIA besides deranged lipid profile. The oxidant-antioxidant imbalance may contribute to the severity of stroke. The levels of serum ACE increase significantly in stroke and TIA patients and are associated with increased severity and worse outcome of cerebrovascular diseases.
No takes yet. Share an insight, caveat, or question.
Kaur et al. (2023) conducted a cross-sectional in Cerebrovascular disorders (Stroke and TIA) (n=120). Cerebrovascular disorders (Stroke and TIA) vs. Healthy controls was evaluated on Serum angiotensin-converting enzyme (ACE) levels (p=<0.004). Serum angiotensin-converting enzyme levels were significantly higher in patients with stroke (27.50 U/L) and TIA (31.60 U/L) compared to healthy controls (22.61 U/L).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: