Key result
NSTEMI patients exhibited a higher rate pressure product compared to healthy controls, which positively correlated with serum ACE activity and oxidative stress markers.
Why the study?
This study aimed to evaluate the impact of lipid profile, cardiac biomarkers, serum ACE activity, oxidative stress, and antioxidant status on BP.
Does the correlation between blood pressure status and various biomarkers (lipid profile, ACE activity, oxidative stress) differ between NSTEMI patients and healthy controls?
Case-Control (n=716)
No
Does the correlation between blood pressure status and various biomarkers (lipid profile, ACE activity, oxidative stress) differ between NSTEMI patients and healthy controls?
In NSTEMI patients, blood pressure and rate pressure product are significantly correlated with lipid profile, serum ACE activity, cardiac biomarkers, oxidative stress, and antioxidant status, suggesting these factors interact to increase myocardial oxygen demand and NSTEMI risk.
Answers are grounded in this paper and cite their sources.
May link oxidative stress markers to BP in NSTEMI; leaves open causal role and need for prospective trials.
The hemodynamic determinants of myocardial oxygen demand measured were heart rate (HR), systolic blood pressure (BP), and rate pressure product (RPP). This study aimed to evaluate the impact of lipid profile, cardiac biomarkers, and serum angiotensin-converting enzyme (ACE) activity, oxidative stress (plasma malondialdehyde, MDA; conjugated diene, DC), and antioxidant status (glutathione peroxidase, GPx) on BP. Three hundred and six non-ST-elevated myocardial infarction (NSTEMI) patients compared to 410 healthy controls. The diastolic and systolic BP was correlated positively with serum ACE activity. The rate pressure product (RPP) was correlated negatively with Fasting glucose (r= -0.144; p = 0.012), HbA1c (r= -0.117; p = 0.041) and GPx activity (r= -0.148; p = 0.009), and positively with smoking (r = 0,197; p = 0.001), BMI (r = 0,219; p = 0.001), peak cTnI (r = 0.131; p = 0.022), serum ACE activity (r = 0,190; p = 0.001) and DC level (r = 0.189; p = 0.001) in NSTEMI patients. Regarding healthy controls, no correlation was found between the diastolic or systolic BP with serum ACE activity, peak cTnI, MDA, DC level, GPx activity, and lipid parameters. The existence of a specific correlation between the rate pressure product, diastolic and systolic BP and, lipid profile, serum ACE activity and, cardiac biomarkers, oxidative stress, and antioxidant status increase the NSTEMI risk on patients.
No takes yet. Share an insight, caveat, or question.
Mehri et al. (2021) conducted a case-control in Non-ST-elevated myocardial infarction (NSTEMI) (n=716). Non-ST-elevated myocardial infarction (NSTEMI) vs. Healthy controls was evaluated on Rate pressure product (RPP) (p=<0.001). NSTEMI patients exhibited a higher rate pressure product compared to healthy controls, which positively correlated with serum ACE activity and oxidative stress markers.
Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context: