Catecholamine Responses to Central Volume Expansion Produced by Head-Out Water Immersion and Saline Infusion*
Key result
Central volume expansion via head-out water immersion significantly decreased plasma norepinephrine levels from a prestudy value of 453 pg/ml to a nadir of 254 pg/ml (P<0.05).
Why the study?
Does central volume expansion via water immersion or saline infusion alter plasma catecholamine levels in healthy adults?
Population
4 salt-replete healthy adults
Comparison
4 hours of thermoneutral head-out water… vs Pre-study and post-study control hours
Design
Other
Follow-up
4 hours per intervention
Authors
Discussion
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Member takes
Implication
Small healthy volunteer data warrant no practice change; leaves open catecholamine contributions to volume natriuresis for patient studies.
Structured PICO
Does central volume expansion via water immersion or saline infusion alter plasma catecholamine levels in healthy adults?
P
Population
4 salt-replete healthy adults subjected to 4 hours of head-out water immersion and 2 liters of normal saline infusion.
I
Intervention
4 hours of thermoneutral head-out water immersion (WI) and infusion of 2 liters normal saline (SI) over 4 hours on two separate occasions
C
Comparator
Pre-study and post-study control hours
O
Outcome
Plasma catecholamine responses (norepinephrine, dopamine, epinephrine)surrogate
Main Result
p-value: p=<0.05
Central volume expansion decreases plasma norepinephrine and increases dopamine, suggesting their relative concentrations may play a role in mediating natriuresis.
Cite This Study
Krishna et al. (1983) studied Healthy (n=4). Central volume expansion (head-out water immersion and saline infusion) vs. Prestudy baseline was evaluated on Plasma norepinephrine levels (p=<0.05). Central volume expansion via head-out water immersion significantly decreased plasma norepinephrine levels from a prestudy value of 453 pg/ml to a nadir of 254 pg/ml (P<0.05).