Why the study?
Does intravascular volume expansion by water immersion elicit natriuresis and neuroendocrine responses in patients with compensated chronic heart failure?
Population
Patients with compensated chronic heart failure and control subjects. A subgroup or cohort of HF patients on…
Comparison
Intravascular and central blood volume expansion… vs Seated control
Design
Other
Follow-up
3 hours
Authors
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Suggests preserved volume natriuresis in compensated HF; leaves open clinical translation to volume management.
Does intravascular volume expansion by water immersion elicit natriuresis and neuroendocrine responses in patients with compensated chronic heart failure?
The neuroendocrine link between volume sensing and renal sodium excretion is preserved in compensated heart failure, though the natriuretic response is modulated by prevailing ANG II and aldosterone levels.
Gabrielsen et al. (2001) studied this question.
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