What question did this study set out to answer?

This research aims to understand how atrial natriuretic factor influences renal sodium and water handling during acute volume expansion.

March 1, 1987Journal of Clinical InvestigationOpen Access

Relationship of increased plasma atrial natriuretic factor and renal sodium handling during immersion-induced central hypervolemia in normal humans.

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Why the study?

Does water immersion-induced central hypervolemia increase plasma atrial natriuretic factor and modulate renal sodium handling in normal humans?

Population

18 healthy male subjects between the ages of 20 and 39 years, with a negative history for hypertension…

Comparison

Water immersion to the neck for 3 hours while… vs Seated quietly outside the immersion tank for a…

Design

Other

Follow-up

5 hours

Authors

MEMurray EpsteinUniversity of Miami RLRodger LoutzenhiserTufts University EFE FriedlandUnited States Department of Veterans Affairs

Discussion

Member takes

Implication

ANF increase during immersion correlates with natriuresis in normals; extends physiologic evidence but leaves open its role in clinical volume disorders.

Key Points

This research aims to understand how atrial natriuretic factor influences renal sodium and water handling during acute volume expansion.
Water immersion to the neck was used to induce hypervolemia in 13 sodium-replete normal subjects.
Plasma ANF, urine flow rate, sodium excretion, plasma renin activity, and aldosterone levels were measured before and after immersion.
ANF levels increased significantly from 7.8 fmol/ml to 19.4 fmol/ml during immersion (P<0.001).
Urine flow rate rose from 2.0 ml/min to 7.0 ml/min (P<0.001) and sodium excretion increased from 92 mu eq/min to 191 mu eq/min (P<0.001).
A strong correlation was found between peak ANF and peak sodium excretion (r=0.67; P<0.025).

Structured PICO

Does water immersion-induced central hypervolemia increase plasma atrial natriuretic factor and modulate renal sodium handling in normal humans?

Population

18 healthy male subjects between the ages of 20 and 39 years, with a negative history for hypertension, cardiovascular disease, diabetes, and clinically apparent renal disease.

Intervention

Water immersion to the neck (NI) for 3 hours while seated, following a 1-hour prestudy period and followed by a 1-hour recovery period.

Comparator

Seated quietly outside the immersion tank for a 5-hour period (time control study).

Outcome

Plasma atrial natriuretic factor (ANF) levels and renal sodium handling (urine flow rate and sodium excretion) during acute volume expansion.surrogate

Acute central hypervolemia induced by water immersion significantly increases plasma ANF levels, which correlates with increased sodium excretion, suggesting ANF plays a physiological role in human volume homeostasis.

Limitations

Sodium balance was not controlled, which may have contributed to variable baseline responses

Cite This Study

Epstein et al. (1987) studied this question.

synapsesocial.com/papers/6a7a28c302ab7a73dd02c0df https://doi.org/10.1172/jci112879

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Implication

ANF increase during immersion correlates with natriuresis in normals; extends physiologic evidence but leaves open its role in clinical volume disorders.

Relationship of increased plasma atrial natriuretic factor and renal sodium handling during immersion-induced central hypervolemia in normal humans.

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Relationship of increased plasma atrial natriuretic factor and renal sodium handling during immersion-induced central hypervolemia in normal humans.

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

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