Why the study?
Does maintaining intrarenal ANG II levels alter the renal response (RIHP, natriuresis, diuresis) to extracellular volume expansion in anesthetized dogs?
Population
Anesthetized dogs
Comparison
Simultaneous infusion of captopril and ANG II… vs Left kidney (no infusion)
Design
Preclinical
Follow-up
45 min
Authors
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Hypothesis-generating in dogs; leaves open whether intrarenal ANG II modulates human renal responses to volume expansion.
Does maintaining intrarenal ANG II levels alter the renal response (RIHP, natriuresis, diuresis) to extracellular volume expansion in anesthetized dogs?
Increases in RIHP, natriuresis, and diuresis during extracellular volume expansion are partially mediated by decreases in intrarenal ANG II levels, especially when plasma ANP levels do not change.
Pinilla et al. (1991) studied this question.
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